This movie is suppose to be a sequel to the movie which starred Jean-Claude Van Damme. Only now the movie revolves around the brother of the character that Van Damme played. David Sloan is the brother Van Damme's Kurt Sloan. He runs a Karate gym. Now Mr. Sangha, the Thai government official who handles Tong Po, the brutal kickboxer whom Van Damme in the previous movie, wishes that Tong Po would have another shot at Kurt Sloan, so he could vindicate himself but Tong Po in a fit of rage shot and killed him thus depriving him of an opportunity to face him again. But when they hear of David, they decide that he will be the one whom Tong Po will face to regain his honor. But when David is injured, Xian David's teacher is brought over to help him with his recovery. And when he recovers, they set David up to fight Tong Po; who will survive?

Gibson Rickenbacker is a hired fighter living in a plague-ravaged apocalyptic America where a plague has infested most of the United States and the rest of the world. In New York City, Gibson encounters a woman named Pearl Prophet. Pearl reveals to Gibson that she is a cyborg who is carrying vital-information for a group of scientists in Atlanta who are working on a cure to the plague and Pearl hires Gibson to escort her back to Atlanta. But Pearl is kidnapped by "Pirates" a murderous gang led by Fender Tremolo, who wants the cure for themselves and they decide to take Pearl to Atlanta themselves. Gibson, joined by a young woman named Nady Simmons, goes in pursuit of Fender and his gang, as Gibson sets out to rescue Pearl, stop Fender and his gang from reaching Atlanta and defeat Fender who slaughtered Gibson's family.